Birthday Gag Gifts

A gag gift for a birthday is way cooler than an ordinary, useable gift. Give the following gag gifts to your loved ones, and see how the person will love you more.

For the always late officemate, give him a backwards clock. Written in reverse, this clock will definitely drive your officemate nuts in no time.

For your conceited teenage sister, give her the laughing mirror. This is the mirror that will laugh every time someone grabs hold of it and looks into it. Your sister would definitely love you more when she gets laughed at by the laughing mirror!

Give fake cat poop to your obsessive-compulsive friend. Scatter it all over her bedroom floor, or, better yet, on her mattress to make her birthday complete.

For your love-sick aunt, give her the art of kissing book. So when she reads it, she gets to crave someone to do the kissing with. For additional fun, include the barf-scent breath freshener so she can enjoy her kissing moments even more!

Your long-haired rocker friend describes the bald head wig. This way, he can have the feeling of having a shaved head for a little while. Or maybe he can even pretend to be a hard-core punk!

The exploding lighter coupled with the exploding cigarette pack is perfect for your buddies who incessantly smoke every time you are together. Nothing will make their day better and your day more hilarious than playing this great prank on them!

If you want your loved ones to love you even more, make sure you give them meaningful gifts that will stick in their memories for the longest time. For that to happen, gag gifts are your best choice.

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.

How To Save Money On Your Heating Bills

How much do you think you spend on your heating bills at present? According to the Energy Saving Trust, on average half the money spent on utility bills in the UK goes towards heating and hot water.

Is it therefore any surprise that come the first sign of winter, many households have the same debate rumbling on, whether to put the heating on. But, did you know that by taking precautionary steps, you can reduce your energy bills at the same time as keeping your home warm. Five top tips we recommend are…

Make an Extra Layer Your First Choice:

Many of us opt to switch the heating on the moment that we feel a chill in the home. Automatically reaching for the heating will cause your energy bills to rocket. Instead, your first option should be to make an extra layer of clothing your first choice to keeping warm.

Have Your Boiler Serviced Annually:

As with all appliances within the home, general usage can take its toll on your boiler. This wear and tear will leave your boiler performing below its optimum level, hindering its efficiency and costing you more in energy bills.

To reduce the risk of wear and tear on your boiler, you should have it serviced annually. Ideally the service should take place before winter takes hold.

Along with getting your boiler serviced, it’s also recommended to install a CO2 alarm next to the boiler.

Bleed Your Radiators:

If you’ve put your heating on and found that the top of your radiator is cooler than the bottom, then you’ll need to bleed them. This isn’t a difficult task, nor is it time consuming. But it is one which should be carried out at the earliest opportunity to save you money on your energy bills.

To bleed your radiators, all you’ll need is a radiator key and a towel.

With your heating off, use the radiator key to turn the valve at the top of the radiator to release any trapped air. Whilst doing this, hold the towel just below the valve to catch any water which may trickle out. As soon as water appears, close the valve.

Set TRVs Low:

Many modern radiators come with TRVs, which enable you to set the temperature of the individual radiator. Whilst many of us will turn the TRV to six, this will cost you money without heating the room any quicker.

To help save money on your energy bills, set the TRV to its lowest setting, before gradually turning them up until you find a comfortable room temperature. It’s also recommend to keep the TRVs on a low setting in rooms which aren’t frequented often. This will help keep the room warm without wasting heat.

Utilise Natural Heat:

OK, so the sun isn’t as strong during the winter months, it can still provide the required warmth to naturally heat your home. To make the most out of the natural warmth from the sun, leave your curtains open during the day, and closed during the evening.

Along with closing your curtains during the evening, it’s also a good idea to keep internal doors closed where possible.

These five simple steps will help you to save money on your heating and energy bills, at the same time as keeping the house warm. But, for those who are looking for an additional heat source there are a number of portable radiators available which will provide the heating requirements you need.

A Holiday in Turkey – Is it the New Spain?

Some four hundred thousand Brits now own holiday homes abroad, Spain has been the most popular of destinations over the past twenty years; it has however become very expensive and more than a little over developed in recent years.

As a consequence many have begun to look elsewhere for their ´place in the sun´. Turkey has seen a huge rise in interest both as a holiday destination and a place to invest in property, people who were astute enough to recognize it as a potential ´hotspot´ as little as eight years ago could have seen their property increase in value by as much as 500% in that time; and whilst Turkey too has seen a decline in demand during 2009, property values have not dropped in the more desirable Mediterranean resorts, (one such resort being Kalkan) to the degree they have in the likes of Spain.

The possibility of Turkey´s acceptance to the European Union has also fuelled speculation in the property market there, whether they will ever achieve acceptance (or indeed actually want to) is yet to be seen. This is the account of how I became one of those ´Brits abroad´: -

I first went to Turkey, rather reluctantly, I might add, on holiday in 2000, and was very pleasantly surprised at how green the country was, I had expected to find a dusty arid country, how wrong I was! I was also very pleasantly surprised at how warm and welcoming the Turkish people were; having holidayed in Greece for some years I had always believed the Greeks would be difficult to beat in their hospitality, the Turks did just that.

My wife and I returned some five years later, having booked a holiday in a very swish hotel on the Dalyan delta, we were disappointed six weeks before being due to depart, to be told by the holiday company that we could not go there as the hotel was having work done and that they, the holiday company, would not allow their guests to have what was not the perfect holiday experience. They told us to choose something else from the brochure and regardless of cost they would honour the price we had paid and even refund us if there was a difference. My wife had seen Kalkan but dismissed it due to the transfer time from the airport feeling that it would be too long, however, given the situation we decided that we would endure the two hour transfer (it turned out to be one and a half). We chose a villa holiday instead of a hotel and hit the jackpot!

Kalkan, we decided very quickly was an idyllic place to holiday and whilst walking down one of the narrow cobbled streets one evening to enjoy a pre-dinner drink stopped to look in an estate agents window (as I´m sure many of you have), before I knew it we were making an appointment with the agent to view some properties the following evening. Meeting that particular agent was yet another amazing stroke of luck, he was a charming intelligent man who´s English was impeccable.

The following evening arrived and I have to say that I personally was not too enthusiastic, as I believed that I was wasting valuable time, I never actually expected to be buying a house. The agent who we learned was called Kemal met us at the appointed time and took us to view the first property, which he had chosen as a possibility. It was an imposing four bedroom detached property with magnificent sea views and a swimming pool; it was newly built and was being marketed at £140,000. It was without doubt a lot of house for the money, however, there was an apartment block right along side it with twelve balconies all of which looked over the swimming pool, a serious privacy issue which immediately ruled that one out.

As we drove away from that villa Kemal asked, “what are you looking for, do you want detached?” I rather facetiously said ´of course´ (remember I had little or no intention of buying) “do you want a swimming pool?” ´ Well obviously!´ He then took us to another newly built in fact not completely finished villa, at what point my attitude changed I cannot actually say, I just knew it was going to happen! This villa again was a four bedroom detached with pool and panoramic views over the bay and astonishingly £15,000 cheaper! We left Kemal that evening feeling like excited school children, a couple of days later and a couple of telephone calls back to the UK to our bank manager and we were signing on the dotted line!

From thereon Kemal did everything we gave him power of attorney (not an easy decision to make with someone you have only just met) and he completed the deal, we became the proud owners of our own piece of paradise seven months later. The piece of paradise is called Villa Katmar, a vaguely Turkish sounding word? No just a combination of parts of our names.

Becoming a property owner in Turkey for us was a very easy and stress free experience, however, a WORD OF WARNING, not everyone we know had such an easy transition into becoming a Turkish villa owner! As in any country it depends very much on the people you deal with and applying a little common sense! I have to say we were very fortunate to have had that almost accidental meeting with Kemal; it could have been a very different tale had we done ´business´ with someone else.

If you are contemplating buying in Turkey then I would urge you to consider Kalkan and if you do then again I would have no hesitation in recommending Kemal Safyurek of Mavi Estates.